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Abstract presented at EUROGIN 2010 “Claudin 1 as a biomarker for cervical cytology and histology”

On Feb 16, 2010

The results indicate high concordance between CLDN1 and CDKN2A immunostaining. CLDN1 might have a similar potential, than CDKN2A, to be used as histological/cytological biomarker to improve the clinical performance of cervical cytology/histology.

The claudin1 (CLDN1) is major component of the tight junction structure and plays an important role in cell-cell adhesion. The role of CLDN1 in
cervical cancer pathology was revealed by our previous work (2). In this study 360 cervical cytological, histological samples were collected
from a colposcopic referral population. The histological and cytological samples were immunostained using CLDN1, and as reference, p16
INK4a /CDK2A antibodies and were evaluated by experienced pathologist.
The results indicate high concordance between CLDN1 and CDKN2A immunostaining, which were in agreement with histology immune status,
as well. CLDN1 might have a similar potential, than CDKN2A, to be used as histological/cytological biomarker to improve the clinical
performance of cervical cytology/histology.

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